BEGIN:VCALENDAR
PRODID:-//planitpurple.northwestern.edu//iCalendar Event//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
CLASS:PUBLIC
BEGIN:VTIMEZONE
TZID:America/Chicago
TZURL:http://tzurl.org/zoneinfo-outlook/America/Chicago
X-LIC-LOCATION:America/Chicago
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:19700308T020000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:19701101T020000
RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
SEQUENCE:0
DTSTART;TZID=America/Chicago:20260605T120000
DTEND;TZID=America/Chicago:20260605T130000
DTSTAMP:20260603T171835Z
SUMMARY:"The recurrent axon collaterals of striatal spiny projection neurons"
UID:642697@northwestern.edu
TZID:America/Chicago
DESCRIPTION: PhD candidate\, Surmeier Lab\, Department of Neuroscience.  The axons of striatal spiny projection neurons (SPNs) have recurrent collateral branches that target neighboring striatal neurons\, including other SPNs. These recurrent collaterals provide a means of rapid local communication and figure prominently in theories of the spatiotemporal pattern of SPN ensemble activity essential for striatal functions in goal-directed movement and a range of cognitive functions\, such as reward processing and decision-making. However\, there are fundamental questions about the functional properties of collateral synapses that remain unanswered\, making assertions about their circuit-level roles speculative. Importantly\, in rodent models of Parkinson's disease (PD)\, the strength of recurrent collateral synapses is dramatically reduced\, paralleling disruptions in ensemble architecture and motor deficits. The mechanisms that modulate SPN collateral synapses\, as well as those underlying the downregulation of functional connectivity in PD\, remain unclear. Ongoing work aims to rigorously characterize SPN collateral function within the striatal circuit and identify the mechanisms driving this functional suppression in PD models. To this end\, a battery of cutting-edge complementary optical\, electrophysiological\, optogenetic\, and anatomical approaches will be used to characterize the physiological and anatomical properties underlying SPN collateral connectivity\, the pathways that modulate these synapses\, and the factors that drive their attenuation in PD models.
LOCATION:Ward Building\, 5-230\, 303 E. Chicago Avenue\, Chicago\, IL 60611
TRANSP:OPAQUE
URL:https://planitpurple.northwestern.edu/event/642697
CREATED:20260602T050000Z
STATUS:CONFIRMED
LAST-MODIFIED:20260602T050000Z
PRIORITY:0
BEGIN:VALARM
TRIGGER:-PT10M
ACTION:DISPLAY
DESCRIPTION:Reminder
END:VALARM
END:VEVENT
END:VCALENDAR