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DTSTART;TZID=America/Chicago:20260915T120000
DTEND;TZID=America/Chicago:20260915T130000
DTSTAMP:20260813T210242Z
SUMMARY:"Neuronal excitation-transcription coupling in health and disease"
UID:644063@northwestern.edu
TZID:America/Chicago
DESCRIPTION:Neuroscience Seminar Series: Mark Dell'Acqua\, Ph.D  Long-term information storage mediated by synaptic plasticity in the brain requires modification of the neuronal transcriptome in response to changes in neuronal activity. This process\, known as excitation-transcription (E-T) coupling\, can be initiated by receptors and ion channels at distal synaptic sites in dendrites\, to trigger long-range signaling via protein kinases and phosphatases to transcription factors\, such as CREB and NFAT\, in the nucleus in the cell soma. Importantly\, E-T coupling is required for normal brain development and learning and memory\, and disruption of synapse-to-nucleus signaling is implicated in neurodevelopmental\, neuropsychiatric\, and neurodegenerative diseases. Through employing a variety of optical stimulation and imaging approaches in combination with genetic and pharmacological manipulations\, we previously found that glutamate receptors activated on distal dendrites can initiate L-type voltage-gated Ca2+ channel (LTCC)-dependent Ca2+ spikes that rapidly propagate from dendrites to the soma to promote calcineurin (CaN) phosphatase-mediated activation NFAT. Furthermore\, this E-T coupling pathway is organized by an AKAP scaffold protein that recruits CaN\, and also the kinase PKA\, to glutamate receptors and LTCCs to control both upstream Ca2+ signal generation in dendrites and downstream propagation to the soma to promote NFAT translocation to the nucleus. Importantly\, new findings will be presented indicating that these AKAP-CaN-NFAT synapse-to-nucleus signaling mechanisms are aberrantly engaged by synaptotoxic amyloid-beta oligomers in Alzheimer’s disease and are disrupted by de novo mutations in the human PPP3CA gene encoding CaNAalpha that cause a developmental epileptic encephalopathy.
LOCATION:Ward Building\, 5-230\, 303 E. Chicago Avenue\, Chicago\, IL 60611
TRANSP:OPAQUE
URL:https://planitpurple.northwestern.edu/event/644063
CREATED:20260812T050000Z
STATUS:CONFIRMED
LAST-MODIFIED:20260812T050000Z
PRIORITY:0
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