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DTSTART;TZID=America/Chicago:20261110T121500
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DTSTAMP:20260912T094232Z
SUMMARY:Microbiology-Immunology Seminar Series: Dr. Montserrat Anguera\, PhD
UID:645757@northwestern.edu
TZID:America/Chicago
DESCRIPTION:Title: Genetic and Epigenetic Influences on Female-Biased Autoimmunity  Description: Women with two X chromosomes are disproportionately affected by autoimmune diseases such as lupus. Our recent studies reveal that maintenance of X-chromosome inactivation in B cells is highly dynamic and relies on both Xist RNA-dependent and Xist-independent mechanisms to preserve the epigenetic state of the inactive X chromosome. In addition\, disrupting Xist RNA-mediated X-chromosome inactivation specifically in B cells can promote aberrant B-cell activation\, autoantibody production\, and lupus-associated disease in female mice. Together\, these findings identify maintenance of X-chromosome inactivation as an important regulator of B-cell function and provide a mechanistic link between the X chromosome and female-biased autoimmunity.
LOCATION:Robert H Lurie Medical Research Center\, Searle Seminar Room\, 303 E. Superior\, Chicago\, IL 60611
TRANSP:OPAQUE
URL:https://planitpurple.northwestern.edu/event/645757
CREATED:20260908T050000Z
STATUS:CONFIRMED
LAST-MODIFIED:20260908T050000Z
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