Description:

Mahnaz Shahidi, PhD
Morton Goldberg Professor in Ophthalmology
Vice Chair and Research Director
University of Illinois at Chicago

Thursday, January14th
6:00 - 7:00pm McGaw – Kellerman Classroom (McGaw 2‐322)
240 E Huron St #1‐200, Chicago, IL 60611
Host: Professor Robert Linsenmeier
*Please bring your Wildcard or Northwestern Medicine ID badge for access to McGaw.

Title:
“Imaging of Retinal Oxygen Delivery and Metabolismy”

Abstract:
Retinal tissue function can be adversely affected by inadequate delivery and/or consumption of oxygen. In fact, derangements in retinal oxygenation are thought to contribute significantly to the development of common vision threatening retinal diseases. However, mechanisms that implicate oxygen in the development of retinal pathologies and impairment of retinal function are not completely understood. Therefore, technologies that allow assessment of oxygen tension in the retinal vasculature and tissue are needed to broaden knowledge of disease pathophysiology, and thereby advance diagnostic and therapeutic procedures. We have developed an optical section phosphorescence lifetime imaging technique that allows depth‐resolved mapping of retinal vascular oxygen tension and measurement of inner retinal oxygen extraction fraction. Combined with fluorescent microsphere imaging for measurement of retinal blood flow, oxygen delivery by the retinal circulation and global inner retinal oxygen metabolism are derived. These technologies have been applied for assessment of retinal oxygen delivery and metabolism in experimental animal models of retinal ischemia.