Northwestern University

Tue 1:00 PM

CMIDD Seminar: Dr. Philip S. Low, Purdue University

When: Tuesday, May 8, 2018
1:00 PM - 2:00 PM  

Where: Robert H Lurie Medical Research Center, Searle Conference Room, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Public - Post Docs/Docs - Graduate Students

Contact: CMIDD   847.467.2991

Group: Center for Molecular Innovation and Drug Discovery

Category: Academic


"Ligand-targeted Imaging and Therapeutic Agents for Cancer, Autoimmune and Infectious Diseases"

Philip S. Low, PhD
Ralph C. Corley Distinguished Professor of Chemistry
Director of the Purdue Institute for Drug Discovery
Purdue University


We have developed small molecule ligands for use in targeting attached drugs specifically to pathologic cells, thereby avoiding the collateral toxicity that usually occurs in healthy cells. In the case of cancer, we began by exploiting up-regulation of a folate receptor on cancers of the ovary, lung, kidney, endometrium and breast to target imaging and therapeutic agents to these cancers. After experiencing success in this area, we then continued by developing additional targeting ligands for delivery of drugs to cancers that do not over-express a folate receptor. Clinical trials of eight of these ligand-targeted drugs demonstrate that the strategy of drug targeting holds considerable promise for increasing drug potency while reducing unwanted toxicity. Data from these clinical trials and the preclinical discovery and development work that preceded them will be presented in this seminar. Videos on the use of these same tumor-targeting ligands to deliver brightly fluorescent near infrared dyes to “light up” cancer tissues during surgeries will also be presented. Finally, because similar ligand-targeted imaging and therapeutic agents have more recently been developed for a number of autoimmune, inflammatory, and infectious diseases (e.g. malaria, rheumatoid arthritis, idiopathic pulmonary fibrosis, multiple sclerosis, psoriasis, atherosclerosis, osteoarthritis, etc.), exciting new preclinical and clinical data on these applications will also be described.

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