Northwestern University

Tue 12:00 PM

BIDS Seminar: Ramana Davuluri, PhD - Faculty Research (Molecular subtyping and drug target discovery at Transcript/Splice Variant (Isoform) Level)

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When: Tuesday, September 25, 2018
12:00 PM - 1:00 PM  

Where: Arthur Rubloff Building, Lakeview Conference Room (11th Floor), 750 N Lake Shore Dr, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Stacia Sliger   312.503.1879

Group: Center for Data Science and Informatics (CDSI)

Category: Lectures & Meetings


With each successive discovery in genetics the dynamic complexity of the gene structure and gene regulation have become increasingly apparent. It’s now understood that the majo¬rity of human genes produce multiple functional products, or isoforms, primarily through alternative transcription and splicing. Different isoforms within the same gene have been shown to participate in different functional pathways, and the altered expression of specific isoforms have been associated with numerous diseases. Consequently, transcriptome analyses based on gene-centric informatics methods; (a) may result in wasted resources in following up “leads” that cannot be replicated because they are false, (b) may result in missing important findings that should have been discovered, and most importantly (c) misinterpretation of the underlying biology. In this talk I will describe some of our recent data science methodologies, which are based on some “old ideas” that account for the underlying splice- and transcript-variants. These informatics methods are illustrated using our recent published studies on platform-independent Informatics pipeline for molecular sub-typing of cancers. I will also discuss our ongoing work on discovery of drug-target genes at isoform/splice-variant level.

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