Northwestern University

Wed 4:00 PM

Evaluation of Nanofibrous 3D Scaffolds for Maintenance of Function and Viability of Primary Hepatocytes In Vitro

When: Wednesday, December 13, 2017
4:00 PM - 5:00 PM  

Where: 676 N. St. Clair Street, Suite 650, Conference Room A, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student

Contact: Lynnette Dangerfield   312.926.7636

Group: Department of Surgery - Research Events

Category: Lectures & Meetings


Jessica Brown, PhD

A major challenge of maintaining primary hepatocytes in vitro is progressive loss of hepatocyte-specific functions, such as protein synthesis and cytochrome P450 (CYP450) catalytic activity. We developed a three-dimensional (3D) nanofibrous scaffold made from poly(L-lactide-co-glycolide) (PLGA) polymer using a newly optimized wet electrospinning technique that resulted in a highly porous structure that accommodated inclusion of primary human hepatocytes. We found that incorporation of ECM components, especially type I collagen, into the PLGA scaffold led to an increase in function of primary human hepatocytes compared to the same cells grown within unmodified PLGA scaffolds.

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