Northwestern University

Mon 12:00 PM

Dr. Argye Hillis-Trupe: Mechanisms of recovery from aphasia: Evidence from Imaging and tDCS

When: Monday, February 12, 2018
12:00 PM - 1:00 PM  

Where: Shirley Ryan AbilityLab, Sky Lobby Auditorium, 10th floor, 355 E. Erie, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Public - Post Docs/Docs - Graduate Students

Contact: Tommi Raij, MD, PhD   312.238.4401

Group: Shirley Ryan AbilityLab Research Seminar Series

Category: Lectures & Meetings



My recent work in post-stroke aphasia has relied on longitudinal functional and structural imaging and cognitive assessments after acute stroke and over the first year of recovery to identify the mechanisms of recovery of language and other cognitive processes. We have been obtaining task-related and task-free (resting state) fMRI studies, perfusion, DTI, and other structural scans and detailed cognitive testing at 4 time points. While others have reported group patterns (e.g. a shift from mostly right hemisphere activation to mostly perilesional left hemisphere activation during language at the chronic stage), we have discovered marked differences in patterns of recovery across individuals and across language tasks within individuals. We have also demonstrated that different mechanisms of recovery (e.g. restoration of blood flow, recovery from diaschisis, reorganization of structure-function relationships) have distinct time courses. This work has led to some novel interventions to augment specific mechanisms at particular stages post-stroke, such as temporary blood pressure elevation to augment restoration of blood flow in acute stroke (pilot randomized trial), transcranial direct current stimulation with language therapy in subacute stroke to augment reorganization of structure-function relationships.


Dr Hillis-Trupe, MD, has long been studying the cognitive and neural bases of naming with multimodality imaging and detailed language testing, as well as methods to improve recovery of naming impairments in individuals with aphasia. She is a cognitive and vascular neurologist with an extensive experience in clinical research involving patients with aphasia. Prior to medical school, she had extensive training and experience as a speech-language pathologist and an investigator in cognitive neuropsychology research. She sees a large number of patients with primary progressive aphasia at Johns Hopkins.

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