Description:

Medial prefrontal cortex local connectivity associated with executive functioning in middle aged adults at risk for cardiovascular disease with Lisanne Jenkins

Midlife cardiovascular risk factors are associated with cognitive decline, structural brain changes and development of dementia. Less is known about the impact of these risk factors on functional brain changes, which often precede structural and clinical changes. We examined resting state functional connectivity in middle aged adults with risk for cardiovascular disease, and found that better executive functioning predicted increased local connectivity of the medial prefrontal cortex and regions involved in inhibitory control.