Description:

Yi-Tao Yu, PhD, Distinguished Professor, Department of Biochemistry and Biophysics, University of Rochester. 

Title: Exploring Pre-mRNA Splicing and Translational Recoding via Targeted RNA Pseudouridylation.”

Abstract: “RNA-guided RNA pseudouridylation is a naturally occurring mechanism in eukaryotic cells. By designing artificial guide RNAs, we have developed systems to investigate the roles of pseudouridine in pre-mRNA splicing and translational recoding. This approach has revealed that snRNA pseudouridylation modulates splicing, while pseudouridylation of mRNA and tRNA contributes to nonsense suppression and codon-specific recoding.”