Description:

Talks will cover the entire range of Biomedical Informatics and Data Science (BIDS) topics. They will include faculty research from NU and other institutions, research by BIDS trainees, and journal club discussions.

Please note that this event is formerly known as CDSI Seminar Series.

Description:

Talks will cover the entire range of Biomedical Informatics and Data Science (BIDS) topics. They will include faculty research from NU and other institutions, research by BIDS trainees, and journal club discussions.

Please note that this event is formerly known as CDSI Seminar Series.

Description:

Talks will cover the entire range of Biomedical Informatics and Data Science (BIDS) topics. They will include faculty research from NU and other institutions, research by BIDS trainees, and journal club discussions.

Please note that this event is formerly known as CDSI Seminar Series.

Description:

"Cancer is a disease comprising dynamic changes in the genome that broadly affect gene expression and gene regulatory networks.  microRNAs (miRNAs) are small noncoding RNA molecules in gene regulatory networks which negatively modulate gene expression post-transcriptionally. In mammalian cells miRNA targeting of genes is nonspecific and can be influenced by genetic variation. In recent years, miRNAs have gained widespread interest since aberrant miRNA function is associated with many diseases, most notably in cancer. Here we investigate how miRNAs regulate genes in cancer in the context of genetic variation. We mine multiple high-dimensional genomic and transcriptomics datasets from The Cancer Genome Atlas (TCGA), a free repository of omics data across several cancer types, and integrate them into an analysis pipeline. Our pipeline identifies a) entire pathways, or systems of genes, that are dysregulated in tumors by miRNAs and b) genomic variants in those pathways that appear to influence miRNA regulation of gene expression in tumors. We then corroborate these results using computational biophysics techniques to better understand their physical basis."

Description:

Medical procedure Never Events, such as “wrong patient, wrong procedure, wrong surgical site errors” (WSPEs) occur 40-80 times or more per week in the U.S. Despite of the introduction of the international standards for surgical safety checklists a decade ago, the rate of surgical Never Event continues to increase. We will examine clinical, workflow, and business challenges to eradicating these errors and how clinical informatics may offer a cure for this systemic disease. It is critical to start the safety process earlier, especially in the ambulatory setting where more than 39% of the WSPEs originate, and to include the patient. In our approach, patient safety checklist information is entered by clinicians during intake, stored on HIPAA-compliant cloud servers, sent to patients or parents for online review, and reviewed by preoperative and operative nursing immediately prior to surgery. These checklists generate documents that can be integrated with electronic health records (EHRs). An initial study of 100 consecutive general surgical pediatric operations demonstrates improved parent and clinician satisfaction with the surgical safety process. The next phase, demonstrating reduction of WSPEs, will involve over 10,000 patients.