Northwestern University

Nov
2
Wed 11:00 AM

Statistics Seminar Series: Combined Hypothesis Testing on Graphs with Applications to Gene Set Enrichment Analysis

When: Wednesday, November 2, 2016
11:00 AM - 12:00 PM  

Where: 2006 Sheridan Road, B02, Evanston, IL 60208 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Cost: Free

Contact: Kisa Kowal   847.491.3974

Group: Department of Statistics

Category: Academic

More Info

Description:

Title: Combined Hypothesis Testing on Graphs with Applications to Gene Set Enrichment Analysis

Professor Ming Yuan
Department of Statistics
University of Wisconsin-Madison, Medical Sciences Center

Abstract:
Motivated by gene set enrichment analysis, we investigate the problem of combined hypothesis testing on a graph. We introduce a general framework to effectively use the structural information of the underlying graph when testing multivariate means. A new testing procedure is proposed within this framework. We show that the test is optimal in that it can consistently detect departure from the collective null at a rate that no other test could improve, for almost all graphs. We also provide general performance bounds for the proposed test under any specific graph, and illustrate their utility through several common types of graphs.

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