Description:

The Department of Pharmacology is pleased to welcome Dr. Matthias Majetschak, M.D., Ph.D. from Loyola University Chicago Stritch School of Medicine. 

Matthias Majetschak, MD, PhD
Professor of Surgery and Molecular Pharmacology & Therapeutics
Interim Co-Director, The Burn and Shock Trauma Research Institute 

The following, is an overview of this seminar, as described by Dr.Majetschak:

The main goal of research in my laboratory is to identify molecular targets for new therapeutic approaches, which are aimed to improve cardiovascular function and reduce secondary organ dysfunction and damage in critical illness. Our more recent studies established ubiquitin as a non-cognate C-X-C motif chemokine receptor 4 (CXCR4) agonist, demonstrated that CXCR4 and atypical chemokine receptor 3 (ACKR3) modulate α1-adrenergic receptor function in vascular smooth muscle and identified that heteromeric complexes between α1-adrenergic receptors and CXCR4 regulate α1-adrenergic receptor function. These studies have directed our current research focus into a new area, the understanding of the roles of receptor heteromerization in the regulation of vascular function and blood pressure control in health and disease.