Northwestern University

May
23
Tue 12:00 PM

The Good and the Bad: Two Faces of Microbiota in the Eye: Rachel R. Caspi, PhD

When: Tuesday, May 23, 2017
12:00 PM - 1:00 PM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Dr. Melissa Brown   312.503.0108

Group: Microbiology-Immunology Seminars

Category: Lectures & Meetings

Description:

Microbiology-Immunology Seminar Series


The commensal microbiome affects affects immunity and immune mediated disease locally as well as in distal sites. Microbiota can play very different roles in inflammatory disease affecting the eye, depending on the context and the location. Our data suggest that intestinal microbiota can serve as a source of crossreactive antigenic material that activates retina-specific T cells that happen to migrate through the gut, and endow them with the ability to cross the blood-retinal barrier and fuel autoimmune disease in the eye. On the other hand, microbiota on the surface of the eye may play a positive role in local host defense, by tuning immune function in the ocular surface mucosa.

Rachel Caspi, PhD

Chief, Immunoregulation Section
Acting Chief, Lab. Immunol., NEI, NIH

Host: Melissa Brown, PhD

Add Event to Calendar

Add Event To My Group:

Please sign-in