Northwestern University

Tue 12:00 PM

The Good and the Bad: Two Faces of Microbiota in the Eye: Rachel R. Caspi, PhD

When: Tuesday, May 23, 2017
12:00 PM - 1:00 PM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Dr. Melissa Brown   312.503.0108

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings


Microbiology-Immunology Seminar Series

The commensal microbiome affects affects immunity and immune mediated disease locally as well as in distal sites. Microbiota can play very different roles in inflammatory disease affecting the eye, depending on the context and the location. Our data suggest that intestinal microbiota can serve as a source of crossreactive antigenic material that activates retina-specific T cells that happen to migrate through the gut, and endow them with the ability to cross the blood-retinal barrier and fuel autoimmune disease in the eye. On the other hand, microbiota on the surface of the eye may play a positive role in local host defense, by tuning immune function in the ocular surface mucosa.

Rachel Caspi, PhD

Chief, Immunoregulation Section
Acting Chief, Lab. Immunol., NEI, NIH

Host: Melissa Brown, PhD

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