Northwestern University

Apr
25
Tue 2:00 PM

"New Insights Into the Structure and Function of the AMPA Receptor N-terminal Domain"

When: Tuesday, April 25, 2017
2:00 PM - 3:00 PM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Public - Post Docs/Docs - Graduate Students

Contact: Alexa Nash   312.503.4893

Group: Department of Pharmacology Seminars

Category: Lectures & Meetings

Description:

The Department of Pharmacology is pleased to welcome Dr. Ingo H. Greger, Ph.D., Programme Leader, Neurobiology Division, MRC Laboratory of Molecular Biology

The following, is an overview of this seminar, as described by Dr.Greger:

AMPA-type glutamate receptors are the main mediators of synaptic
transmission and plasticity. Recruitment of these glutamate-gated channels
to synapses is a central mechanism to increase synaptic strength, which
underlies learning. Recent progress in structural biology has led to an
understanding of AMPA receptor architecture. Combined with coarse-grained
simulations these insights have revealed the substantial flexibility of
the AMPA receptor complex. In this talk I will highlight some of these
advances and will discuss how dynamic rearrangements likely shapes
receptor operation at synapses. A particular focus will be the large AMPA
receptor N-terminal domain.

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