Northwestern University

Wed 4:00 PM

Maturation of iPSC-derived Hepatocytes in 3D Co-culture

When: Wednesday, April 26, 2017
4:00 PM - 5:00 PM  

Where: 676 N. St. Clair Street, Suite 650, 6th Floor Conference Room A, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student

Contact: Lynnette Dangerfield   312.926.7636

Group: Department of Surgery - Research Events

Category: Lectures & Meetings


Michael DiVito, PhD

Hepatocyte transplantation has been shown to partially correct metabolic deficiencies. This therapy could be used to temporarily improve metabolic function for patients waiting for a donor organ. Induced pluripotent stem cells (iPSCs), which can be differentiated into hepatocyte-like cells (iPSCHs), could be used for transplantation in place of primary hepatocytes. However, the main limitation of iPSCHs is a blunted phenotype with decreased functionality (P450 and synthetic function) compared to fresh human hepatocytes. The work presented discusses how various 3D co-culture configurations have been used to improve the maturation of iPSCHs.

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