Maturation of iPSC-derived Hepatocytes in 3D Co-culture

Michael DiVito, PhD

Hepatocyte transplantation has been shown to partially correct metabolic deficiencies. This therapy could be used to temporarily improve metabolic function for patients waiting for a donor organ. Induced pluripotent stem cells (iPSCs), which can be differentiated into hepatocyte-like cells (iPSCHs), could be used for transplantation in place of primary hepatocytes. However, the main limitation of iPSCHs is a blunted phenotype with decreased functionality (P450 and synthetic function) compared to fresh human hepatocytes. The work presented discusses how various 3D co-culture configurations have been used to improve the maturation of iPSCHs.

Add Event To My Group

Please sign-in