Northwestern University

May
18
Thu 10:00 AM

BMG Seminar: Why Bad Things Happen to Good Chromosomes - David Pellman, MD

When: Thursday, May 18, 2017
10:00 AM - 11:00 AM  

Where: Robert H Lurie Medical Research Center, Searle Seminar Room, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Carson Nestler   312.503.5229

Group: Biochemistry & Molecular Genetics Seminar Series

Category: Lectures & Meetings

Description:

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents:

David Pellman, MD
Margaret M. Dyson Professor of Pediatric Oncology and Professor of Cell Biology
Harvard Medical School
Principal Investigator, Pediatric Oncology, Dana-Farber Cancer Institute
Investigator, Howard Hughes Medical Institute 

Chromosome segregation errors in cancer result in abnormal nuclear architecture, a phenomenon known as know nuclear atypia. Micronuclei are one feature of nuclear atypia. We recently demonstrated that micronuclei are the origin of a novel mutational process called chromothripsis. Chromothripsis is massive chromosome rearrangement limited to one or a few chromosomes. The chromosome damage from micronuclei appears to occur secondary to spontaneous nuclear envelope disruption. I will discuss chromothripsis and present a new model explaining the basis for the nuclear envelope fragility of the micronuclei.

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