Northwestern University

Tue 12:00 PM

Microbiology-Immunology Department: David Ucker, PhD

When: Tuesday, October 17, 2017
12:00 PM - 1:00 PM  

Where: Robert H Lurie Medical Research Center, Baldwin, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Dr. Stephen D. Miller   312.503.7674

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings


The Department of Microbiology-Immunology Seminar Series

"Apoptotic Immunity is Subverted in Microbial Pathogenesis"

David Ucker, PhD - University of Illinois


As cells die apoptotically (regardless of the mode of apoptosis induction), they paradoxically gain a new ability to exert potent immunosuppression. The response to apoptotic cells (“Innate Apoptotic Immunity”; IAI) represents a ubiquitous and unconventional immunity. We find that the exploitation of IAI is one strategy that pathogens employ to evade host immunity. This is particularly evident in the case of infection by Listeria monocytogenes, where the extensive induction of apoptosis in host cells, which can be substituted by the introduction of uninfected, exogenous apoptotic cells, not provide a niche for bacterial replication and rather alters host immunity, enhancing pathogenesis substantially.

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