Northwestern University

Jan
16
Tue 12:00 PM

Microbiology-Immunology Department: Patrick Woida

When: Tuesday, January 16, 2018
12:00 PM - 1:00 PM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Dr. Karla Satchell   312.503.2162

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings

More Info

Description:

The Department of Microbiology-Immunology Seminar Series

"Vibrio cholerae MARTX Toxin Effector Domains Rewire the Innate Immune Response of Intestinal Epithelial Cells"

Patrick Woida, Graduate Student, Lab of Karla Satchell, PhD / Northwestern University

Description


Abstract: While the recent outbreaks of Vibrio cholerae in Haiti and Yemen made global headlines, endemic V. cholerae still disproportionally affects Africa and Asia. Many of the strains from these regions carry multifunctional autoprocessing repeats-in-toxin (MARTX) toxins to enhance virulence. MARTX toxins are pore-forming effector delivery toxins that translocate functionally distinct effector domains into the cytosol of the target cell. The role of the MARTX toxin during pathogenesis still remains elusive. While the three effector domains of the V. cholerae MARTX toxin have been characterized, the role of the MARTX toxin during infection is most likely a combined result of all three effectors. Therefore, exploring how the other effectors modulate the host response to individual effector activity is essential to understand how the MARTX toxin promotes pathogenesis. These studies have identified a role of the effector domains in rewiring intestinal innate immunity in response to not only the bacteria but also to individual effector function.

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