Northwestern University

Sep
20
Thu 10:00 AM

BMG Seminar: Gene essentiality and druggable genetic dependencies in KSHV-transformed primary effusion lymphoma - Eva Gottwein, PhD

When: Thursday, September 20, 2018
10:00 AM - 11:00 AM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Beverly Kirk   312.503.5217

Group: Biochemistry & Molecular Genetics Seminar Series

Category: Lectures & Meetings

Description:

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents:

Eva Gottwein, PhD
Assistant Professor of Microbiology-Immunology
Northwestern University Feinberg School of Medicine

The oncogenic herpesvirus Kaposi’s Sarcoma-associated herpesvirus (KSHV) causes primary effusion lymphoma (PEL), a highly aggressive cancer with few treatment options. I will present recent data from genome-wide CRISPR/Cas9 essentiality screens that have revealed the cellular gene essentiality landscape in PEL derived cell lines. Our new work addresses how KSHV may usurp cellular pathways to gain transcriptional control over the essential genes that promote survival and proliferation in PEL. We have finally built on this work to explore the potential utility and mechanisms of action of the immunomodulatory drugs lenalidomide and pomalidomide in PEL.

 

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