The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents:
Eva Gottwein, PhD
Assistant Professor of Microbiology-Immunology
Northwestern University Feinberg School of Medicine
The oncogenic herpesvirus Kaposi’s Sarcoma-associated herpesvirus (KSHV) causes primary effusion lymphoma (PEL), a highly aggressive cancer with few treatment options. I will present recent data from genome-wide CRISPR/Cas9 essentiality screens that have revealed the cellular gene essentiality landscape in PEL derived cell lines. Our new work addresses how KSHV may usurp cellular pathways to gain transcriptional control over the essential genes that promote survival and proliferation in PEL. We have finally built on this work to explore the potential utility and mechanisms of action of the immunomodulatory drugs lenalidomide and pomalidomide in PEL.
Beverly Kirk
(312) 503-5217
Email