Northwestern University

Wed 4:00 PM

"Contributions of Protocadherins, PCDH12 and PCDH19, to Cortical Development and Brain Connectivity Defects"

When: Wednesday, September 19, 2018
4:00 PM - 5:00 PM  

Where: Ward Building, 5-230, 303 E. Chicago Avenue, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Donna Daviston   312.503.1687

Group: Physiology Roundtables

Category: Lectures & Meetings


Alicia Guemez Gamboa, Ph.D., Assistant Professor, Physiology

Developing neurons integrate into functional circuits through a series of cell recognition events, which include neuronal sorting, axon and dendrite patterning, synaptic selection, among others. Our research focuses on cell-surface recognition molecules that mediate interactions between neurons to discriminate and select appropriate targets in the developing brain. Additionally, we seek to uncover novel mechanisms of neural recognition that lead to brain connectivity defects in humans. In this talk, I will highlight the characterization of disease mechanisms pertaining to PCDH19-epilepsy, and the evidence we have so far to support the role of non-clustered PCDHs (PCDH12 and PCDH19) in cortical development and disease.

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