The Simpson Querrey Center for Epigenetics presents:
Yamini Dalal, PhD
Senior Investigator, Receptor Biology and Gene Expression
Group Director, Chromatin Structure and Epigenetic Mechanisms Group
National Cancer Institute, Bethesda, MD
Title: Journey to the Black Hole of the Human Genome
Abstract: Unique chromatin structures dictate the functional fate of specific regions of the genome. Centromeres, encoded by the histone variant CENP-A, play an essential role in mitosis. In this lecture, I will discuss the naturally elastic nature of human centromeres, and discuss how such unique biophysical features can hijack non-centromere pathways to drive fragility at subtelomeric breakpoints in the cancer epigenome.
Beverly Kirk
(312) 503-5217
Email