When:
Tuesday, November 13, 2018
12:00 PM - 1:00 PM CT
Where: Robert H Lurie Medical Research Center, Hughes Auditorium, 303 E. Superior, Chicago, IL 60611 map it
Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students
Contact:
Dr. Eva Gottwein
(312) 503-3075
Group: Department of Microbiology-Immunology Seminars/Events
Category: Lectures & Meetings
Title: "CRISPR/Cas9 Genetic Analysis of the Epstein-Barr Virus Lifecycle
Benjamin Gewurz, MD, PhD
Harvard University
Hosts: Dr. Eva Gottwein and Richard Longnecker
Description:
Epstein-Barr virus is associated with multiple human cancers, including lymphomas of immunosuppressed hosts, Burkitt and Hodgkin lymphoma, nasopharyngeal and gastric carcinomas. To gain insights into host factors that control key aspects of the EBV lifecycle, we are using CRISPR/Cas9 screens and temporal proteomic maps of viral latent and lytic infection states. This approach is highlighting vulnerabilities that may ultimately be exploited to selectively target EBV-infected cancers.