Microbiology-Immunology Department: Benjamin Gewurz, MD, PhD

Title: "CRISPR/Cas9 Genetic Analysis of the Epstein-Barr Virus Lifecycle

Benjamin Gewurz, MD, PhD

Harvard University

Hosts: Dr. Eva Gottwein and Richard Longnecker

Description:

 Epstein-Barr virus is associated with multiple human cancers, including lymphomas of immunosuppressed hosts, Burkitt and Hodgkin lymphoma, nasopharyngeal and gastric carcinomas. To gain insights into host factors that control key aspects of the EBV lifecycle, we are using CRISPR/Cas9 screens and temporal proteomic maps of viral latent and lytic infection states. This approach is highlighting vulnerabilities that may ultimately be exploited to selectively target EBV-infected cancers.
 

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