Microbiology-Immunoogy Department: James A. Imlay, PhD

"Molecular Explanations for the Toxicity of Oxygen"

Speaker: James A. Imlay, PhD -University of Illinois at Urbana-Champaign

Host: Bacteriology Students, Coordinator Linda I-Lin Hu, PhD

TOPIC

For more than 100 years we have understood that high levels of oxygen are overtly toxic and that lower levels chronically damage organisms of all types. This phenomenon has a large impact upon where microbes live, their vulnerability to immune responses, and even their pace of evolution. We have worked to tease apart both the details of damage and the strategies by which cells defend themselves. Recent work has compared how oxygen injures aerotolerant organisms with how it blocks the growth of obligate anaerobes.

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