Northwestern University

Tue 12:00 PM

Microbiology-Immunology Department:Daniel Giraldo

When: Tuesday, February 26, 2019
12:00 PM - 1:00 PM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Dr. Richard Longnecker   312.503.3075

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings


" Immunoregulatory Targeting of the Type 1 IFN Response Protects Against Mortality in a Murine Model of Neonatal HSV-1 Encephalitis"

Speaker: Daniel Giraldo, Driskill Graduate Program, Lab of Richard Longnecker, PhD


Newborn infection with herpes simplex virus (HSV) is a serious, life-threatening condition with an incidence of 1 in 3,200 deliveries in the U.S. Unlike adult infections, which are commonly asymptomatic, over 50% of neonatal HSV infections result in disseminated disease or encephalitis. However, the nature of these age-dependent differences to HSV infection remains largely understudied. Here we explore how intrinsic differences in the type I IFN pathway in the central nervous system between the adult and the newborn correlate with increased susceptibility to HSV-1 infection and how this pathway can be modulated to provide protection to the newborn. Our studies will provide important insights into the mechanisms controlling age-dependent differences in the innate immune response to CNS injury throughout development and may lead to novel therapeutic approaches.

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