"Endosomal TLRs are Major Pathways to Recognizing Legionella pneumophila in Human Macrophages"
Speaker: Lubov Grigoryeva, Driskill Graduate Program, Lab of Nicholas Cianciotto, PhD
TOPIC
Legionella pneumophila is a gram-negative bacterium that causes a severe form of pneumonia known as Legionnaire’s disease. Preliminary data from our laboratory revealed that the recognition of wild-type L. pneumophila by human macrophages deviates from previously reported pathways in murine macrophages, calling into question the field’s reliance on murine-based experimentation. My project seeks to understand the mechanisms of innate immune signaling in human macrophages after Lp infection.
Dr. Nicholas Cianciotto
(312) 503-0385
Email