David Nagib, PhD
Assistant Professor of Chemistry
Department of Chemistry
Ohio State University
"C-H and C-O Functionalization via Radical Chaperones"
Abstract
Our research is focused on harnessing the untapped reactivity of abundant chemical feedstocks to enable late-stage functionalization of medicinally relevant molecules. We have recently developed new approaches for selective C-H and C-O functionalization of alcohols, amines, and carbonyls, using a combination of radical (1e-) and closed shell (2e-) processes that act in concert with one another. These radical chaperone strategies have enabled discovery of new classes of reactivity to streamline the synthesis of complex molecules with biological and industrial significance.
Co-sponsored by CMIDD and Department of Chemistry. This is a Chemical Biology and Drug Discovery Research Cluster event. Faculty host is Professor Julia Kalow.