Northwestern Events Calendar

Nov
15
2019

"Tongue Kinematics. Cortex-dependent corrections as the mouse tongue reaches for, and misses, targets"

When: Friday, November 15, 2019
12:00 PM - 1:00 PM  

Where: Ward Building, 5-230, 303 E. Chicago Avenue, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Donna Daviston   312.503.1687

Group: Department of Physiology Seminars

Category: Lectures & Meetings

Description:

The department of Physiology welcomes Jesse Goldberg, M.D., Ph.D.

Precise control of the tongue is necessary for drinking, eating, and vocalizing. Yet because tongue movements are fast and difficult to resolve, neural control of lingual kinematics remains poorly understood. We combine kilohertz frame-rate imaging and a deep-learning based artificial neural network to resolve 3D tongue kinematics in mice performing a cued lick task. Cue-evoked licks exhibit previously unobserved fine-scale movements which, like a hand searching for an unseen object, were produced after misses and were directionally biased towards remembered locations. Photoinhibition of anterolateral motor cortex (ALM) abolished these fine-scale adjustments, resulting in well-aimed but hypometric licks that missed the spout. Our results show that cortical activity is required for online corrections during licking and reveal novel, limb-like dynamics of the mouse tongue as it reaches for, and misses, targets.

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