“New tools to record neuronal network dynamics in models of disease.”

The department of Physiology welcomes Peyman Golshani, Ph.D.

We have developed new open-source miniaturized microscopy tools to to record neuronal dynamics in freely behaving animals. These tools include wireless miniaturized microscopes, large-field of view scopes, light field miniaturized microscopes for 3-dimensional imaging, multichannel miniaturized microscopes, and microscopes integrated with multichannel electrophysiology. These tools are being shared with the community through miniscope.org as they are each finalized. We have used some of these tools to record network dynamics in the hippocampus of a temporal lobe models of epilepsy. We have found dramatic imprecision and instability of place cells in these models.

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