When:
Tuesday, October 8, 2019
12:00 PM - 1:00 PM CT
Where: Simpson Querrey Biomedical Research Center, Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it
Audience: Faculty/Staff - Post Docs/Docs - Graduate Students
Contact:
Dr. Mojgan Naghavi
(312) 503-4294
Group: Department of Microbiology-Immunology Seminars/Events
Category: Lectures & Meetings
Title: How Viral and Cellular RNAs Protect Themselves from Nonsense-Mediated mRNA Decay
Speaker: J. Robert Hogg, PhD, NIH
Host: Mojgan Naghavi, PhD
Topic:
The nonsense-mediated mRNA decay (NMD) pathway performs quality control and regulatory functions in virtually all eukaryotic cells. Best known for detecting and degrading mRNAs containing mutations that cause premature translation termination events, NMD also targets viral and cellular mRNAs with features such as upstream open reading frames and long 3’ untranslated regions. Using retroviral RNAs as models, we have identified proteins important for the protection of viral and cellular mRNAs from decay. The mechanisms and functional consequences of NMD evasion will be discussed.