Northwestern Events Calendar


Department of Microbiology-Immunology: Jonathan Kipnis, PhD

When: Tuesday, October 22, 2019
12:00 PM - 1:00 PM  

Where: McGaw Pavilion, Williams Auditorium, 240 E. Huron, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Dr. Lavanya Visvabharanthy   312.503.1093

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings


Title: Meningeal Lymphatics in CNS Immune Surveillance and in Neuroinflammation

Speaker: Jonathan Kipnis, PhD

Host: Immunology Graduate Students and Postdocs


Immune cells and their derived molecules have major impact on brain function. Mice deficient in adaptive immunity have impaired cognitive and social function compared to that of wild-type mice. Importantly, replenishment of the T cell compartment in immune deficient mice restored proper brain function. Despite the robust influence on brain function, T cells are not found within the brain parenchyma, a fact that only adds more mystery into these enigmatic interactions between T cells and the brain. Our results suggest that meningeal space, surrounding the brain, is the site where CNS-associated immune activity takes place. We have recently discovered a presence of meningeal lymphatic vessels that drain CNS molecules and immune cells to the deep cervical lymph nodes. This communication between the CNS and the peripheral immunity is playing a key role in immune surveillance of the CNS and in several neuroinflammatory disorders.

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