Northwestern Events Calendar

Sep
20
2019

Department of Microbiology-Immunology: Richard P. Sora, PhD

When: Friday, September 20, 2019
2:00 PM - 3:00 PM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Dr. Richard Longnecker   312.503.0467

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings

Description:

Title:

"Epstein-Barr Virus Latent Membrane Protein 2A Accelerates Lymphoma Development Through p27Kip1 Degradation and Increased PRMT5 Expression"

Speaker

Richard P. Sora, Ph.D.Northwestern University - Driskill Graduate Program in Life Sciences
Management for Scientists and Engineers Certification - Kellogg Business School
Carcinogenesis Training Grant Recipient

Host

Richard Longnecker, PhD

Topic

Burkitt lymphoma (BL) is a B cell cancer that develops primarily in children and is associated with Epstein-Barr virus (EBV). The EBV latent membrane protein 2A (LMP2A) accelerates tumor development in a mouse model of BL. My studies show blocking degradation of the cell cycle regulatory protein  p27Kip1 prevents this accelerated tumor development.  I also show LMP2A expression results in increased levels of protein arginine methyltransferase 5 (PRMT5), which may also contribute to the accelerated tumor development driven by LMP2A.

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