Title:
"Epstein-Barr Virus Latent Membrane Protein 2A Accelerates Lymphoma Development Through p27Kip1 Degradation and Increased PRMT5 Expression"
Speaker
Richard P. Sora, Ph.D.Northwestern University - Driskill Graduate Program in Life Sciences
Management for Scientists and Engineers Certification - Kellogg Business School
Carcinogenesis Training Grant Recipient
Host
Richard Longnecker, PhD
Topic
Burkitt lymphoma (BL) is a B cell cancer that develops primarily in children and is associated with Epstein-Barr virus (EBV). The EBV latent membrane protein 2A (LMP2A) accelerates tumor development in a mouse model of BL. My studies show blocking degradation of the cell cycle regulatory protein p27Kip1 prevents this accelerated tumor development. I also show LMP2A expression results in increased levels of protein arginine methyltransferase 5 (PRMT5), which may also contribute to the accelerated tumor development driven by LMP2A.
Dr. Richard Longnecker
(312) 503-0467
Email