Northwestern Events Calendar

Dec
10
2019

Department of Microbiology-Immunology: Joseph Sun, PhD

When: Tuesday, December 10, 2019
12:00 PM - 1:00 PM  

Where: Simpson Querrey Biomedical Research Center, Simpson Querry Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Dr. Chyung-Ru Wang   312.503.9748

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings

Description:

Title: Epigenetic Control of Innate and Adaptive Lymphocyte Responses

Speaker : Joseph Sun, PhD

Host: Chyung-Ru Wang, PhD

Topic:

Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrated that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate that differentiating and ‘memory’ NK cells possess distinct chromatin accessibility states, and that their epigenetic profiles reveal a ‘poised’ regulatory program at the memory stage. Furthermore, we elucidate how individual STAT transcription factors differentially control epigenetic and transcriptional states early during infection. Finally, concurrent chromatin profiling of the canonical CD8+ T cell response against the same infection demonstrated parallel and distinct epigenetic signatures defining NK cells and CD8+ T cells. Overall, our study reveals the dynamic nature of epigenetic modifications during the generation of innate and adaptive lymphocyte memory. 

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