Northwestern Events Calendar


Department of Microbiology-Immunology: Chan-Wang "Jerry" Lio, PhD

When: Thursday, January 16, 2020
10:00 AM - 11:00 AM Central

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Dr. Chyung-Ru Wang   (312) 503-9748

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings


Title: Epigenetic Regulation of B Cell Response

Speaker: Chan-Wang Lio, PhD, La Jolla Institute

Host: Chyung-Ru Wang, PhD


The B-cell-mediated antibody response is essential for the protection against pathogens. Following maturation, B cells progressively demethylate their DNA, a process with unknown physiological significance and consequence. Here, we showed that TET (Ten-Eleven Translocation)-mediated DNA modification and demethylation are required for efficient antibody isotype switching in B cells. The 5-methylcytosine oxidases TETs modify the DNA at the super-enhancer and facilitate the expression of AID (Activation-induced cytidine deaminase), the essential enzyme for antibody maturation.  Thus, our study shows that proper epigenetic regulation in B cells is fundamental to a productive antibody response.  Further investigations of the epigenome may provide new avenues to modulate and improve vaccination outcomes.           

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