Department of Microbiology-Immunology: E. Antoinio Chiocca, MD, PhD

Title:  Gene and Viruses as Therapeutics for Cancer

Speaker: E. Antonio Chiocca, MD, PhD / Harvard University

Host:  Pablo Penaloza-MacMaster, PhD

Topic:

Pathogens, such as viruses, can be turned into therapeutic modalities for a variety of diseases such as cancer, by genetic modification to turn them into gene therapy vectors or into cancer-selective infectious agents (oncolytic viruses).  Glioblastoma is a deadly brain cancer.  We have utilized gene therapy and oncolytic viral approaches to cause direct cytotoxicity and also stimulate immune responses against this cancer in mouse models and clinical trials in humans.  I will discuss the biology of these approaches and the current state of clinical trials. 

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