CANCELLED: CANCELLED: Peptidoglycan Fragment Production by the Pathogenic Neisseria - Joseph Dillard, PhD

Title:

Peptidoglycan Fragment Production by the Pathogenic Neisseria 

Speaker: Joseph Dillard, PhD / University of Wisconsin-Madison

Host: Hank Seifert, PhD

Topic:

The pathogenic Neisseria produce and release small fragments of the cell wall as the bacteria grow. These peptidoglycan fragments include molecules that are agonists for the pattern-recognition receptors NOD1 and NOD2. Human Fallopian tube tissue produces an inflammatory response to the peptidoglycan fragments that results in death and sloughing of ciliated epithelial cells, damage that is partly responsible for the sequlae of pelvic inflammatory disease. We work to understand the mechanisms involved in production of the peptidoglycan fragments, the consequences of mutating genes for peptidoglycan breakdown, and the host responses to Neisseria in human organ culture models of infection. 

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