CANCELLED
When:
Tuesday, March 31, 2020
12:00 PM - 1:00 PM CT
Where: Simpson Querrey Biomedical Research Center, SQBRC Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it
Audience: Faculty/Staff - Post Docs/Docs - Graduate Students
Contact:
Dr. Hank Seifert
(312) 503-9788
Group: Department of Microbiology-Immunology Seminars/Events
Category: Lectures & Meetings
Title:
Peptidoglycan Fragment Production by the Pathogenic Neisseria
Speaker: Joseph Dillard, PhD / University of Wisconsin-Madison
Host: Hank Seifert, PhD
Topic:
The pathogenic Neisseria produce and release small fragments of the cell wall as the bacteria grow. These peptidoglycan fragments include molecules that are agonists for the pattern-recognition receptors NOD1 and NOD2. Human Fallopian tube tissue produces an inflammatory response to the peptidoglycan fragments that results in death and sloughing of ciliated epithelial cells, damage that is partly responsible for the sequlae of pelvic inflammatory disease. We work to understand the mechanisms involved in production of the peptidoglycan fragments, the consequences of mutating genes for peptidoglycan breakdown, and the host responses to Neisseria in human organ culture models of infection.