Northwestern Events Calendar


CANCELLED: Peptidoglycan Fragment Production by the Pathogenic Neisseria - Joseph Dillard, PhD


When: Tuesday, March 31, 2020
12:00 PM - 1:00 PM  

Where: Simpson Querrey Biomedical Research Center, SQBRC Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Dr. Hank Seifert   312.503.9788

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings



Peptidoglycan Fragment Production by the Pathogenic Neisseria 

Speaker: Joseph Dillard, PhD / University of Wisconsin-Madison

Host: Hank Seifert, PhD


The pathogenic Neisseria produce and release small fragments of the cell wall as the bacteria grow. These peptidoglycan fragments include molecules that are agonists for the pattern-recognition receptors NOD1 and NOD2. Human Fallopian tube tissue produces an inflammatory response to the peptidoglycan fragments that results in death and sloughing of ciliated epithelial cells, damage that is partly responsible for the sequlae of pelvic inflammatory disease. We work to understand the mechanisms involved in production of the peptidoglycan fragments, the consequences of mutating genes for peptidoglycan breakdown, and the host responses to Neisseria in human organ culture models of infection. 


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