Northwestern Events Calendar

Feb
6
2020

"What do Mitochondrial Patients tell us about Parkinson's disease?"

When: Thursday, February 6, 2020
12:00 PM - 1:00 PM  

Where: Ward Building, 5-230, 303 E. Chicago Avenue, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Donna Daviston   312.503.1687

Group: Department of Physiology Seminars

Category: Lectures & Meetings

Description:

The department of Physiology welcomes Amy Reeve, Ph.D.

Abstract

Mitochondrial dysfunction is believed to be a key player in the pathogenesis of Parkinson’s disease, through its contribution to the degeneration of dopaminergic neurons. However, defects within this organelle are also detected in the same neurons, in normal ageing and mitochondrial diseases. However, mitochondrial dysfunction not always associated with significant neurodegeneration in these cases. Thus, we are interested in understanding how neurons respond to accumulating mitochondrial dysfunction, and whether such adaptive capabilities may be lost in Parkinson’s. In this seminar, I will discuss our work using post mortem brain tissue, as we aim to determine what differs between the response of dopaminergic neurons to mitochondrial dysfunction in Parkinson’s compared to the mitochondrial diseases. I will also present new data from imaging mass cytometry, with which we can understand the intricate relationships between mitochondrial protein expression in single neurons.

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