Northwestern Events Calendar


Department of Microbiology-Immunology Virtual Seminar: Dean Procter, PhD

When: Tuesday, June 30, 2020
12:00 PM - 1:00 PM Central

Where: Online
Webcast Link

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Dr. Derek Walsh   312.503.4292

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings


Seminar Title:

Control of Intranuclear Polarity by a Hyperactive Microtubule Organizing Center Formed During Human Cytomegalovirus Infection

Speaker: Dean Procter, PhD/ Walsh Lab

Host: Derek Walsh, PhD, Professor, Dept. of Microbiology-Immunology


By developing deep-learning assisted image classification pipelines we have been able to detect progressive polarization of the host nucleus during human cytomegalovirus (HCMV) infection. Polarity is induced towards the viral cytoplasmic assembly compartment, which we previously discovered to be a hyperactive Golgi-derived microtubule organizing center (MTOC), and is coupled to nuclear rotation events. Polarity is induced first at the nuclear membrane and eventually forms within host heterochromatin. Mechanotransduction from this viral MTOC in the cytoplasm to the host nucleus is required for efficient HCMV replication.  

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Meeting ID: 920 2876 7029 
Password: 089805

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