Description:

Seminar Title:

Control of Intranuclear Polarity by a Hyperactive Microtubule Organizing Center Formed During Human Cytomegalovirus Infection

Speaker: Dean Procter, PhD/ Walsh Lab

Host: Derek Walsh, PhD, Professor, Dept. of Microbiology-Immunology

Topic:

By developing deep-learning assisted image classification pipelines we have been able to detect progressive polarization of the host nucleus during human cytomegalovirus (HCMV) infection. Polarity is induced towards the viral cytoplasmic assembly compartment, which we previously discovered to be a hyperactive Golgi-derived microtubule organizing center (MTOC), and is coupled to nuclear rotation events. Polarity is induced first at the nuclear membrane and eventually forms within host heterochromatin. Mechanotransduction from this viral MTOC in the cytoplasm to the host nucleus is required for efficient HCMV replication.  

Zoom Link:

Join Zoom Meeting 
https://northwestern.zoom.us/j/92028767029?pwd=N0JZYm94dXJ1RGtOQUY1TGdPajh4UT09

Meeting ID: 920 2876 7029 
Password: 089805