Description:

Title: Exploring Novel Iron Uptake Mechanisms in Legionella pneumophila” 

Speaker : Alberto Lopez, Graduate Student, Cianciotto Lab

Host: Nicholas Cianciotto, PhD

Topic:

Legionella pneumophilia (Lp) is a Gram-negative bacterium that inhabits freshwater systems, surviving much of the time as an intracellular parasite of amoebae. Yet, Lp is best known as the causative agent of Legionnaires’ disease, a severe form of pneumonia that primarily impacts the immunocompromised and elderly. During infection, Lp replicates within alveolar macrophages. Iron acquisition is an important feature of Lp ecology and pathogenesis. Among other things, my lab has found that Lp secretes a low-molecular weight, non-proteinaceous Fe3+ chelator (siderophore), known as rhizoferrin. Utilizing transcriptomics as a starting point, my project is uncovering new and novel aspects of Lp iron acquisition and regulation. 

Exploring Novel Iron Uptake Mechanisms in Legionella pneumophila” . 

Speaker: Alberto Lopez, Graduate Student / Cianciotto Lab

Host: Nicholas Cianciottto, PhD

Topic: TBA