Northwestern Events Calendar


"Cortical Disinhibitory Circuits: Cell Types, Connectivity and Function"

When: Friday, October 9, 2020
12:00 PM - 1:00 PM  

Where: Online

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Donna Daviston   312.503.1687

Group: Department of Physiology Seminars

Category: Lectures & Meetings


The Department of Physiology welcomes Dr. Lisa Topolnik with Université Laval.


The concept of a dynamic excitation/inhibition ratio due to circuit disinhibition, which can shape information flow in cortical circuits during complex behavioral tasks, has arisen as an important and conserved information processing motif. Indeed, in cortical circuits, different subtypes of GABAergic inhibitory interneurons are connected to each other. Moreover, a subpopulation of GABAergic cells that express vasoactive intestinal polypeptide (VIP) selectively innervates inhibitory interneurons. In both cases, circuit disinhibition is a possible outcome of interneuron-to-interneuron signaling. My talk will focus on inhibitory neuron subtypes that are involved in hippocampal disinhibition, with focus on local circuit and long-range synaptic connections that drive disinhibitory function. 

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