Northwestern Events Calendar

Dec
11
2020

"Striatal Dopamine Waves as a Mechanism for Spatiotemporal Credit Assignment"

When: Friday, December 11, 2020
12:00 PM - 1:00 PM  

Where: Online

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Donna Daviston   312.503.1687

Group: Department of Physiology Seminars

Category: Lectures & Meetings

Description:

The Department of Physiology welcomes Dr. Arif Hamid with Brown University.

Significant evidence supports the view that dopamine shapes reward-learning by encoding prediction errors. However, it is unknown whether dopamine decision-signals are tailored to the functional specialization of target regions. In this talk, I will report on a novel set of wave-like spatiotemporal activation patterns in dopamine axons and release across the dorsal striatum that switch between different activational motifs. At reward delivery, waves are altered by task demands, propagating on the mediolateral axis and predict trial-by-trial instrumental behavioral adjustments and agency learning in mice. I will demonstrate that our results are consistent with a computational architecture in which striatal dopamine signals are sculpted by inference about agency, and provide evidence for a spatiotemporally “vectorized” role of dopamine in credit assignment that are directed toward specialized “expert” striatal subregions.

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