Northwestern Events Calendar

Jan
19
2021

Striatal GPCR-Based Neuromodulation and its Behavioral Implications

When: Tuesday, January 19, 2021
10:00 AM - 11:00 AM Central

Where: Online

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Liz Murphy   312.503.4892

Group: Department of Pharmacology Seminars

Category: Lectures & Meetings

Description:

Department of Pharmacology Faculty Candidate

Shana M. Augustin, Ph.D.
Postdoctoral Research Fellow 
National Institutes of Health    
National Institute on Alcohol Abuse and Alcoholism
Laboratory for Integrative Neuroscience

Abstract:
Striatal neuromodulators play a critical role in motor control, decision-making and addiction. Neuromodulators exert their functions through G-protein-coupled receptors that activate second messenger intracellular cascades to affect neuronal signaling, both short- and long-term synaptic modifications. Thus, understanding the cellular, subcellular, and synaptic mechanisms underlying neuromodulation is critical to advancing our knowledge of striatal function. The focus of my recent research has been the action of dopamine on different cellular populations of striatal dopamine D2 receptors in the induction of endocannabinoid-dependent long-term depression, the downstream signaling of the cAMP-PKA pathway, as well as their behavioral implications

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