The Department of Biochemistry and Molecular Genetics presents:
Chia-Lin Wei, Professor and Director, Genome Technologies
The Jackson Laboratory, Farmington, CT
Title: Harnessing Genomic Technologies for Insights into Chromatin Architecture and Transcriptional Regulation
Advancing our ability to interrogate genomes is the driving force for biomedical discovery and technology innovation. Cutting-edge genome technologies enable us to survey genetic inheritance and epigenetic changes throughout development, disease progression and in responses to environmental influences. In this talk, I will discuss exciting development in ultra-long read sequencing to determine the complex structural variation and using chromatin interaction analyses to characterize the 3D chromatin structures associated with cancer-promoting changes, specifically, the roles of extra-chromosomal DNA in transcriptional amplification and tumor evolution. Our strategies offer exciting possibility of targeting chromatin architectures for cancer therapy.
Beverly A Kirk
(312) 503-5217
Email