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Biochemistry and Molecular Genetics Departmental Seminar Series: Chia-Lin Wei, PhD, The Jackson Laboratory

When: Thursday, April 7, 2022
10:00 AM - 11:00 AM Central

Where: Simpson Querrey Biomedical Research Center, Simpson Querry Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Beverly A Kirk   (312) 503-5217

Group: Biochemistry & Molecular Genetics Seminar Series

Category: Academic


The Department of Biochemistry and Molecular Genetics presents:

Chia-Lin Wei, Professor and Director, Genome Technologies
The Jackson Laboratory, Farmington, CT

Title: Harnessing Genomic Technologies for Insights into Chromatin Architecture and Transcriptional Regulation

Advancing our ability to interrogate genomes is the driving force for biomedical discovery and technology innovation. Cutting-edge genome technologies enable us to survey genetic inheritance and epigenetic changes throughout development, disease progression and in responses to environmental influences. In this talk, I will discuss exciting development in ultra-long read sequencing to determine the complex structural variation and using chromatin interaction analyses to characterize the 3D chromatin structures associated with cancer-promoting changes, specifically, the roles of extra-chromosomal DNA in transcriptional amplification and tumor evolution. Our strategies offer exciting possibility of targeting chromatin architectures for cancer therapy.

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