Title: “Seeing the CNS Through The Eyes/Genetics Of HIV-1”
Ron Swanstrom, PhD
Professor
Department of Biochemistry & Biophysics, Dept. of Microbiology and Immunology,
University of North Carolina School of Medicine
Faculty Host: Mojgan Naghavi, PhD
Topic:
HIV-1 can be found in CSF throughout viral infection raising the possibility of infection within the CNS. However, the CNS environment is very different compared to the lymphoid tissues that usually support viral replication. As a result of this difference the virus both undergoes a distinct evolutionary pathway to allow long term growth in resident CNS cells, and also has distinct interactions with inflammatory cells that migrate into the CNS. These unique interactions between HIV-1 and the CNS have implications for pathogenesis and for the latent reservoir.
Cynthia Naugles
(312) 503-0489
Email