Northwestern Events Calendar

Jan
11
2022

M-I Dept. Seminar Series - "Defining the Genetic Factors Required for Gastrointestinal Colonization Across Klebsiella pneumoniae Strains"

When: Tuesday, January 11, 2022
12:00 PM - 1:00 PM Central

Where: Simpson Querrey Biomedical Research Center, Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Cynthia Naugles   (312) 503-0489

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings

Description:

Title: 

"Defining the Genetic Factors Required for Gastrointestinal Colonization Across Klebsiella pneumoniae Strains"

Bettina Cheung, Graduate Student, DGP, Lab of Alan Hauser MD, PhD

Faculty Host: Alan Hauser, MD, PHD

Topic:

As a leading cause of nosocomial infections, Klebsiella pneumoniae poses a significant clinical threat due to its propensity to acquire resistance to many classes of antibiotics, including carbapenems. Gastrointestinal colonization by K. pneumoniae is a risk factor for subsequent infection as well as transmission to other patients. To study this crucial step in pathogenesis, we developed a mouse model of K. pneumoniae GI colonization using a clinically relevant parenteral antibiotic regimen. As K. pneumoniae has a rich accessory genome (genetic material not shared by all strains), we will use this animal model to perform high-throughput screens of a variety of phylogenetically distinct strains to define the genetic factors required for GI colonization in K. pneumoniae.  

 

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