M-I Dept. Seminar Series - Cell Intrinsic Control of Viral Infection

Title: Cell Intrinsic Control of Viral Infection

John Schoggins, PhD, Associate Professor, Dept. of Microbiology, UT Southwestern Medical Center

Faculty Host: Derek Walsh, PhD

Topic:

Mammalian cells control viral infection through the well characterized interferon response, and through less well studied interferon-independent cell intrinsic restriction factors. This presentation will focus on 1) the mechanism of recently identified cell intrinsic antiviral protein TRIM7, an E3 ligase that inhibits replication of diverse enteroviruses, and 2) viral evasion strategies that enteroviruses have developed to counteract TRIM7. This work reveals new molecular insight into virus-host interactions for a class of viruses with broad pathogenic effects in humans. 

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