When:
Tuesday, April 5, 2022
12:00 PM - 1:00 PM CT
Where: Simpson Querrey Biomedical Research Center, Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it
Audience: Faculty/Staff - Post Docs/Docs - Graduate Students
Contact:
Cynthia Naugles
(312) 503-0489
Group: Department of Microbiology-Immunology Seminars/Events
Category: Lectures & Meetings
Title: Cell Intrinsic Control of Viral Infection
John Schoggins, PhD, Associate Professor, Dept. of Microbiology, UT Southwestern Medical Center
Faculty Host: Derek Walsh, PhD
Topic:
Mammalian cells control viral infection through the well characterized interferon response, and through less well studied interferon-independent cell intrinsic restriction factors. This presentation will focus on 1) the mechanism of recently identified cell intrinsic antiviral protein TRIM7, an E3 ligase that inhibits replication of diverse enteroviruses, and 2) viral evasion strategies that enteroviruses have developed to counteract TRIM7. This work reveals new molecular insight into virus-host interactions for a class of viruses with broad pathogenic effects in humans.