Neuroscience Seminar: Dr. Joshua Goldberg | "GIN (GABAergic interneurons) & TONIC activity of cholinergic interneurons put a brake on striatal spiny projection neurons"

Joshua Goldberg, PhD 
Associate Professor   
Department of Medical Neurobiology
The Hebrew University of Jerusalem   

Abstract: 

In my talk I will describe two of our recent studies of how cholinergic interneurons (CINs) impact striatal processing. In the first part, I will demonstrate that CINs delay the spiking of spiny projection neurons via tonic activation of nicotinic acetylcholine receptors on GINs. In the second part, I will propose that dendritic nonlinearities in CINs (that we interrogate optogenetically) help them differentially process their two afferent excitatory inputs from cortex and thalamus.

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