When:
Tuesday, November 1, 2022
12:00 PM - 1:00 PM CT
Where: Simpson Querrey Biomedical Research Center, SQBRC Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it
Audience: Faculty/Staff - Post Docs/Docs - Graduate Students
Contact:
Cynthia Naugles
(312) 503-0489
Group: Department of Microbiology-Immunology Seminars/Events
Category: Lectures & Meetings
Title: Innate Immune Responses to Viruses by OAS-RNase L
Speaker: Robert H. Silverman, PhD, Professor and Staff, Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH
Topic:
The 2’,5’-oligoadenylate (2-5A) synthetase (OAS)-RNase L pathway mediates the interferon response against a wide range of different types of viruses. Intriguingly, many coronaviruses and rotaviruses express enzymes that eliminate 2-5A allowing for viral evasion of RNase L, and of interferon. OAS-RNase L also impacts viral pathology by regulating inflammatory responses to virus infections. Current studies that focus on effects of OAS-RNase L on SARS-CoV-2 infections will be described.
Host: Virology Postdocs and Graduate Students