M-I Dept. Seminar Series / Innate Immune Responses to Viruses by OAS-RNase L

Title: Innate Immune Responses to Viruses by OAS-RNase L

Speaker:  Robert H. Silverman, PhD, Professor and Staff, Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH

Topic:

The 2’,5’-oligoadenylate (2-5A) synthetase (OAS)-RNase L pathway mediates the interferon response against a wide range of different types of viruses.  Intriguingly, many coronaviruses and rotaviruses express enzymes that eliminate 2-5A allowing for viral evasion of RNase L, and of interferon.  OAS-RNase L also impacts viral pathology by regulating inflammatory responses to virus infections.  Current studies that focus on effects of OAS-RNase L on SARS-CoV-2 infections will be described.

Host: Virology Postdocs and Graduate Students

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