Northwestern Events Calendar


M-I Dept. Bacteriology Faculty Candidate - The Microbial Arms Race Across Kingdoms: From cGAS to CRISPR-Cas

When: Monday, November 14, 2022
10:00 AM - 11:00 PM CT

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Cynthia Naugles   (312) 503-0489

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings


Title: The Microbial Arms Race Across Kingdoms: From cGAS to CRISPR-Cas


Nicole Marino, PhD, University of California San Francisco


Bacteria encode diverse antiviral defense systems, including CRISPR-Cas and cGAS, that are conserved across kingdoms. Many bacterial viruses (phage), in turn, encode proteins to inactivate these defenses. Here, I will present evidence that a phage-encoded anti-CRISPR specifically inhibits Cas12a biogenesis by triggering translation-dependent mRNA degradation. This novel strategy by a virus to disarm bacterial immunity appears to be widespread and may impact diverse microbial and molecular conflicts. 


Bacteriology Search Committee

M.-N. Frances Yap, PhD, Committee Chair

Dept. of Microbiology-Immunology

Northwestern University Feinberg School of Medicine

Chicago, IL


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