Description:

The Simpson Querrey Institute for Epigenetics presents:

Diego Pasini, PhD

Group Leader, Department of Experimental Oncology, European Institute of Oncology Professor, Department of Health Sciences, University of Milan

"Epigenetic Control of Transcriptional Identity: A Gastrointestinal Perspective on Tissue Homeostasis and Cancer Development"

Establishing and maintaining cellular identities involves multiple signals that instruct the activity of transcription factors and chromatin-remodeling activities to define cellular transcriptional states. Such control mechanisms play crucial roles in human pathologies and are directly implicated in the development of several type of cancers. The lecture will be focused on the recent advancements of our laboratory to uncover distinct roles of Polycomb activities in regulating gastrointestinal cell fates and tissue homeostasis, and on the distinct oncogenic properties of WNT signaling mutations across gastrointestinal stem cells.